Searchable abstracts of presentations at key conferences in endocrinology

ea0063p623 | Diabetes, Obesity and Metabolism 2 | ECE2019

Myeloproliferative disorder: a rare cause of insulin auto-immune syndrome leading to recurrent severe hypoglycaemia

Emna Jelloul , Fontaine Benedicte , Vanderbecken Stephane , Meliani Pascal , Kembellec Candice , Flaus-Furmaniuk Ania , Debussche Xavier

Insulin autoimmune syndrome (IAS; Hirata syndrome) is a rare cause of hypoglycemia. It seems to be related to specific HLA class II alleles. Rarely, monoclonal antibody acts as an insulin-binding autoantibody: until now 10 cases have been described in association with a myeloproliferative disorder. In June 2015, a 60-year-old patient presented in a local hospital in Mayotte with confusion, sweating and severe hypoglycemia (blood glucose as low as 20 mg/dl). He was suffering of...